Over the recent years the events gathering crowds of people such as the Olympic Games, the FIFA World Cup or continental championships in football, the religious celebrations on a large scale, etc. are usually assisted by security protection activities. They are among others, the medical protection and sanitary - epidemiological surveillance. It is even said to distinguish of the mass gatherings medicine, which has been discussing in medical sciences since 1986. Also in reference to the intensive sanitary and epidemiological surveillance which assists such the events, there can be declared that we are observing now the arising of the specific kind of protection namely, the sanitary-epidemiological protection of mass events. Organizing UEFA EURO 2012 together with Ukraine, Poland also faced the problem of preparing the appropriate sanitary – epidemiological protection of that event. The activities of National Sanitary Inspection and cooperating services are presented in this paper, in particular in the organizational sphere.